Background:Wound healing is a complex process and has been an ongoing challenge all over the world. Some studies have suggested light cure as a modality to accelerate wound repair. It can induce fibroblast proliferation, increase collagen synthesis and activate cellular processes involved in expression of procollagen type I and III mRNA. This study was designed to assess the macroscopic effect of halogen dental curing blue light on full-thickness open wound healing in NMRI mice.Materials and Methods:Forty male NMRI mice were divided into control and treatment groups. A full-thickness wound of 6 mm in diameter was induced on the lower back of all mice under general anesthesia and sterile conditions. The mice of the treatment group received a 5-min exposure of halogen light Coltolux II (QHL), 420-500 nm, daily for 7 days. The diameter of the wound was measured in both the treatment and the control groups every second day up to Day 14. Data were analyzed by SPSS version 12 software using Student's t-test. A significance level of P ≤ 0.05 was considered for each comparison.Results:There was a significant difference in wound diameter between the control and the treatment groups at all measurements after Day 3 (P ≤ 0/05).Conclusion:The results of this study suggest improvement of full-thickness wound healing by daily irradiation of halogen dental curing blue light of 420-500 nm for 7 days.
Introduction: The aim of this study was to evaluate the salivation flow rate objectively using Schirmer test; and mouth dryness and other consequences subjectively by distributing questionnaires to patients receiving head and neck radiotherapy. Materials and Methods: In this descriptive study that was carried out at Imam Khomeini hospital, Tehran, Iran, the saliva flow rate of 33 patients receiving radiotherapy was evaluated in millimeter in 5 minutes using Schirmer test (with a filtered paper calibrated from 1 to 35mm) before treatment, two weeks and four weeks after and at the end of treatment thus having four groups of measurements. Mouth dryness and other consequences were recorded by questionnaire at final stage. Friedman test, chisquare, dependent and independent t-tests were applied to analyze the data. Results: In all four groups, the mean of the saliva flow rate decrease during treatment was significant and followed a descending pattern. At the end of the treatment, the total received dosage and saliva flow rate had an inverse relationship, (P value=0.000). The mean salivation decrease in bilateral radiation was estimated more than unilateral one; though their relation was not statistically significant (P value=0.251). The mean salivation decrease in bilateral radiation of nasopharyngeal cancer was meaningfully greater than unilateral (P value 0.05). Conclusion: During radiation, saliva flow rate depends on the total dosage and the radiation site. Increasing the total dosage of radiation and the field diameter would result in the decrease of salivation of the major salivary glands, particularly parotid ones.
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