Significance
Comprehending the responses of organisms to pollutants by a systems-based approach allows characterization of molecular events and the cellular pathways that have been perturbed. However, mapping only adverse outcomes of a toxicant in an organism falls short of describing the defense response that is mounted to maintain homeostasis and resistance to the toxic insult. Our study provides the understanding of molecular mechanisms of algae in response to silver, which in turn indicates how the algae might behave in a silver contamination scenario. We have used complementary information obtained from the transcriptome, proteome, and physiology to gain mechanistic insights into the responses of
Chlamydomonas reinhardtii
. We show here the importance of stress and adaptive responses, especially at sublethal concentrations of pollutant.
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