A simple, green protocol has been accomplished for the synthesis of amidoesters 5 a-k in choline chloride/urea (1:2) through multicomponent reaction of 3-formyl chromone, Meldrum's acid, isocyanides and primary alcohols via a domino reaction. Carrying out the reaction using trifluoroethanol led to succinimide derivatives 6 a-d. Easy work-up, selectivity, and good to excellent yields are the advantages of this protocol.
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