The diagnosis of fat embolism syndrome (FES) may present with a constellation of symptoms and continues to be a diagnosis of exclusion. Fat embolism syndrome is a poorly understood syndrome, which is typically associated with orthopedic trauma, most commonly with long bone fractures. Understanding the presentation of FES is essential to provide timely and appropriate interventions and to ensure optimal patient outcomes. The following is a case report of FES in a 39-year-old man following a motor vehicle collision in which he sustained a comminuted fracture of the right femur. The patient was subsequently diagnosed with FES using Gurd criteria in conjunction with frequent assessment of the patient's clinical picture, as well as exclusion of other differential diagnoses. Nurse practitioners and other providers should understand the constellation of symptoms that may be associated with FES to improve prevention and ensure timely intervention.
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