PurposeThough the socioeconomic burden of cancer on patients is increasing in South Korea, there is little research regarding the type of cancer that incurs the highest costs. This study analyzed the socioeconomic burden on cancer patients from 2011 to 2015 according to sex and age.Materials and MethodsA prevalence-based approach was applied utilizing claim data of the National Health Insurance Service in Korea to estimate the socioeconomic burden of cancer on patients. Patients who received treatment for cancer from 2011 to 2015 were the study subjects. The total socioeconomic burden of their disease and treatment was divided into direct and indirect costs.ResultsThere was an increase of 50.7% for 5 years, from 821,525 to 1,237,739 cancer patients. The cancer costs for men and women increased $8,268.4 million to $9,469.7 million and $3,626.5 million to $4,475.6 million, respectively. Furthermore, the 50-59-year-old age group accounted for a large portion of the total disease cost. Liver, lung, stomach, and colorectal cancers created the heaviest economic burdens on patients.ConclusionOverall, this study indicates new policies for cancer prevention, early detection, and postcancer treatment management are necessary to help limit the costs associatedwith cancer, especially in the elderly, and provides a foundation for establishing cancer-related health care policies, particularly by defining those cancers with heavier disease burdens.
ObjectivesThis study, different from the past researches, has been conducted in all age groups to understand the association between air pollutants, pollen risk indexes, and outpatients with allergic rhinitis (AR), asthma, and atopic dermatitis (AD).MethodsData on air pollutants, pollen risk indexes, and outpatients with each disease were collected from 2003 through 2011 to verify the association between them. All data are time-series materials that have been observed by time (day) and region, and are in a nonlinear shape. In particular, the total number of outpatients per day is a count data that had a Poisson distribution as the response variable. SAS 9.3 was used to make a statistical model, generalized additive model, with lag effects for the analysis.ResultsFor allergic diseases during spring (April–May) and fall (September-October), a significant association was shown between the variables of air pollutants, pollens, and the number of outpatients. Especially, the estimates of NO2 [AR (43.00967 ± 0.11284), asthma (52.01837 ± 0.06452), AD (52.01837 ± 0.06452), p < 0.001] in spring and SO2 [AR (43.00967 ± 0.11284), asthma (52.01837 ± 0.06452), AD (52.01837 ± 0.06452), p < 0.001] in fall were highly significant and showed a positive association with all diseases.ConclusionDomestically and even internationally, various studies on the allergic diseases are being conducted. However, not many studies related to similar studies. In the need of creating grounds to back up these efforts, additional studies on allergic diseases, as well as researches utilizing pollen data, air pollution data, and claims data provided by the Health Insurance Corporation that has no problem in the representativeness of the data that have close relationships to the allergic disease will be needed.
Objectives:To investigate trends in the prevalence of allergic disease over a 9-year period.Methods:Using National Health Insurance Service (NHIS) data, the annual number of patients with allergic disease was obtained for each regional subdivisions (small cities, counties, and districts) from 2003 to 2011. Annual populations for each sub-region were obtained and used to calculate the standardized prevalence. To compare prevalence within the study period, data was standardized spatially and temporally. For standardization, demographic data was used to obtain the registered population and demographic structure for 2010, which was used to perform direct standardization of previous years. In addition, a geographic information system (GIS) was used to visualize prevalence for individual sub-regions, and allergic diseases were categorized into five groups according to prevalence.Results:The nationwide outpatient prevalence of allergic rhinitis increased approximately 2.3-fold, from 1.27% in 2003 to 2.97% in 2013, while inpatient prevalence also increased approximately 2.4-fold,. The outpatient prevalence of asthma increased 1.2-fold, and inpatient prevalence increased 1.3-fold. The outpatient prevalence of atopic dermatitis decreased approximately 12%, and inpatient prevalence decreased 5%.Conclusions:There was a large difference between prevalence estimated from actual treatment data and prevalence based on patients’ self-reported data, particularly for allergic rhinitis. Prevalence must continually be calculated and trends should be analyzed for the efficient management of allergic diseases. To this end, prevalence studies using NHIS claims data may be useful.
Recently, an advanced microcolumn concept for improved throughput was proposed. However, due to the complexity of the approach, the miniaturization was limited. In addition, microcolumns must run under ultrahigh vacuum conditions in order to obtain stable electron emission at the field-emission tip. Both signal and power lines need to be connected through the ultrahigh vacuum chamber. Therefore, increases in the number of microcolumn arrays necessitate more wiring from the external control unit to the internal units, and the number of wires can become prohibitive. To solve this problem, a new concept, exploiting the possibility of an arrayed microcolumn which uses microelectromechanical systems (MEMS) technology has been developed. This paper describes a monolithic (3 ϫ 3 arrayed) microcolumn, which consists of a cold field-emission tip, an input lens, an einzel lens, and novel deflectors for multiple-arrayed microcolumns. We also describe its fabrication process, which relies on improved microfabrication and MEMS technology, most notably multiwafer anodic bonding techniques and copper electroplating for the double metallization process. This paper describes an electro-optical analysis and an optimization using an equivalent circuit and a newly proposed simulation tool. We focus on the production possibilities for microcolumns constructed using MEMS technology. The emission current of the fabricated tungsten and molybdenum cold field-emission tip was several microamperes for an applied gate voltage of 100 V. The probe current, which was measured in the sample grid of the wafer stage, was about 1 nA. The amount of electron-beam deflection was proportional to the applied voltage at the deflector, and operated at about 1 m/V.
In this article, we describe the models and the results of a new three dimensional (3D) lithography simulation programs for low energy (∼1 keV) electron beam systems. Monte Carlo simulation was performed to obtain the energy intensity distribution in e-beam resists, and the models we have used were tabulated Mott data for elastic scattering, Moller and Vriens cross sections for inelastic scattering, and modified Bethe equation plus discrete energy loss for energy loss. The energy intensity in poly(methyl) methacrylate was calculated with the exposure simulation program with various pattern shapes. In the development simulation program, the 2D or 3D resist profile could be implemented. The ray tracing model and the Neureuther equation were used for the development simulation. The simulated developed depths as a function of energy were compared with experimental results developed by Rishton and Schock. The maximum deviation from the experimental results was 12.4 nm (6%) at 2500 eV, and all the data were within error range. The optimum condition was obtained and the positive and negative resist profiles for 50 nm line and space pattern were realized with our simulation program.
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