a b s t r a c tThis paper reviews key issues in the physical and numerical modelling of marine renewable energy systems, including wave energy devices, current turbines, and offshore wind turbines. The paper starts with an overview of the types of devices considered, and introduces some key studies in marine renewable energy modelling research. The development of new International Towing Tank Conference (ITTC) guidelines for model testing these devices is placed in the context of guidelines developed or under development by other international bodies as well as via research projects. Some particular challenges are introduced in the experimental and numerical modelling and testing of these devices, including the simulation of Power-Take-Off systems (PTOs) for physical models of all devices, approaches for numerical modelling of devices, and the correct modelling of wind load on offshore wind turbines. Finally, issues related to the uncertainty in performance prediction from model test results are discussed.

The effects of iontophoretically applied opiates were tested on 24 spinothalamic tract cells in 12 anesthetized monkeys. The drugs used were chosen because of their agonist actions on different classes of opiate receptors (mu, morphine; kappa, dynorphin; delta, methionine enkephalinamide; sigma, N-allylnormetazocine or SKF 10047 and phencyclidine). The actions of the opiate drugs were generally inhibitory, although excitatory or mixed effects were sometimes seen, especially with morphine and dynorphin. Drug effects could change, depending on the position of the iontophoretic electrode array or on the current employed. Naloxone sometimes antagonized the action of the opiate drugs used, but naloxone did not seem to be a drug suited for iontophoretic application. A number of explanations are discussed to explain the variable actions of the opiate drugs.