Allergen-specific immunotherapy and allergen reduction which are interventions in allergic disease have potential to + + reduce long-term allergy symptoms. A decrease on CD8 type 2 and T CD4 cells correlates with regulatory mechanisms of immunotherapy. So far, there is no study evaluating the effect of long-term administration of immunotherapy, probiotics, + + and Nigella sativa on modulation of immune response, especially CD4 /CD8 T cells ratio, immunoglobulin E (IgE) level, and + + asthma scoring. This research design was randomized clinical trials (RCTs), pre-post control study for CD4 /CD8 T cells ratio, IgE level, and asthma scoring. The subjects were divided into four groups, immunotherapy+placebo, immunotherapy+Nigella sativa, immunotherapy+probiotics, and immunotherapy+Nigella sativa+probiotics. All treatments were given in 56 weeks. Immunotherapy conducted was house dust mite (HDM) subcutaneous 9 immunotherapy. Probiotic given was ProBi (Medifarma) containing 2x10 colony forming unit (cfu)/gram Lactobacillus + + acidophilus and Bifidobacterium lactis. Asthma scoring was assessed using Asthma Control Test scores. CD4 /CD8 T cell ratio was measured using flowcytometry, and IgE level was measured using Chemiluminescence Enzyme Immunoassay.
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