Oocyte growth occurs in follicles, and follicular fluid (FF) is the sole environment for developing oocytes and granulosa cells (GCs). FF contains a myriad molecules that support oocyte growth, and fatty acids are a major component. Polyunsaturated fatty acids (PUFAs) consist of approximately half of the fatty acids in human FF, 1 and n-3 PUFA, α-linolenic acid (ALA, C18:3 n-3), eicosapentaenoic acid (EPA, C20:5 n-3), and docosahexaenoic acid (DHA, C22:6 n-3) are crucial, because mammals cannot produce ALA, a precursor of the other PUFA, and the only source of PUFA is food. Six-week omega 3 dietary intake improved embryo development markers in humans; shorter time to complete four cell cycle and synchrony for the third cell cycle, and high concentration of serum ω3PUFA were associated
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