Zoledronic acid therapy decreased the incidence of SREs and improved the 1-year survival rate of patients with bone metastases from bladder cancer, potentially through its anticancer activity.

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Background: Superior sulcus tumors are a complex subset of tumors accounting for less than 5% of lung tumors. Methods: Twenty-three patients admitted between 2001 and 2007 were included in the study,. Computed tomography scan of the chest was considered the primary diagnostic and staging investigation for all patients. Radiation therapy was given preoperatively to 20 patients, neoadjuvant chemotherapy was given to 13 patients. Results: There were 22 men and one woman in the study. The mean age was 53 years. Lobectomy was performed in 20 patients and wedge resection was done for three patients. Three to five ribs were resected in all patients. Extended resections were performed in eight patients. Positive mediastinal lymph nodes were found six patients. The staging was: Stage IIB (11 patients); Stage IIIA (four patients), Stage IIIB (six patients) and Stage IV (two patients). Negative resection margin was achieved in 18 patients. Postoperative complications developed in nine patients, there was one operation related mortality. Tumor recurrence developed in 16 patients. The mean survival time was 2.8 years and the overall 5-years survival was 26%. Conclusion: Multimodality treatment gives satisfactory results with low morbidity and mortality rates and acceptable survival.

Background: Correlation analysis between functional outcomes and different factors (pouch, stoma, ISR type, age and sex) revealed: Pouch formation and type of ISR had significant correlations with some functional aspects. Aim of the Study: To evaluate the oncologic safety and functional outcomes of Intersphincteric Resection (ISR) as an alternative to Abdominoperineal Resection (APR) in low rectal cancer. Patients and Methods: Patients presenting to the National Cancer Institute, Cairo University from May 2014 to October 2014; with locally advanced low (3-6m from the anal verge) rectal cancer and ended their long-course neoadjuvant chemoradiotherapy were subjected to ISR if eligible. These patients were assessed and followed for the short-term outcomes of ISR. Results: Twenty one patients underwent ISR. There was no mortality. Ten patients had postoperative complications. All cases had free distal margin and one patient had +ve radial margin. The Improvement of all functional aspects occurred with time. Kirwan's grade of continence by the 15 th month was: I: 5/16 (31.3%), II: 8 (50%) and III: 3 (18.8%). This is very clear comparing it with 3 rd month results: II: 3/19 (15.8%), III: 13 (68.4%) and IV: 3 (15.8%). Conclusion: Intersphincteric resection is an oncologically safe alternative to the standard APR in low rectal cancer, with the added benefit of improving the quality of life by avoiding a permenant stoma, together with acceptable functional outcomes.