RO and its complications, BO and benign oesophageal stricture increase with age. RO, BO and stricture are more common in absolute and relative terms among younger men than younger women. RO and stricture increase more rapidly in women than men so that the prevalence in elderly patients is similar in both sexes.
This is the first description of an investigation for the positive diagnosis of irritable bowel syndrome, and for diagnosing inflammatory bowel disease.
Introduction
VOCs can be utilised as non invasive biomarkers for gastrointestinal diseases such as IBD, as changes in VOCs reflect internal metabolical and pathological processes.
Methods
Patients were recruited from outpatients with proven Crohn’s disease(CD N = 41), ulcerative colitis(UC N = 49), IBS(N = 30) and healthy volunteers(N = 47). Disease activity was recorded using Harvey-Bradshaw index(HBI) in CD and simple clinical colitis activity index(SCCAI) in UC. Faecal headspace gas was sampled with SPME and transferred to GC-MS for VOC identification. Statistical analysis was performed on presence or absence and peak area of VOCs.
Abstract PTU-076 Table
Number of VOCs found per association on analysis of peak-area using Mann-Whitney U test
UC inactive (SCCAI≤2)
UC active (SCCAI≥3)
CD inactive (HBI≤3)
CD active (HBI≥4)
UC inactive (SCCAI≤2)
-
2 VOCs (P = 0.007–0.018)
9 VOCs (P = 0.011–0.039)
NIL
CD active(HBI≥4)
-
-
1 VOC (P = 0.038)
NIL
IBS
8 VOCs (P = 0.016–0.041)
-
2 VOCs (P = 0.027–0.029)
9 VOCs (P = 0.02–0.046)
Healthy
20 VOCs (P = 0.017–0.048)
6 VOCs (P = 0.008–0.047)
19 VOCs (0.001–0.048)
21 VOCs (P = 0.004–0.044)
Please note: table restrictions and character limitations donot allow compound names to be embedded. Full results will be included within the presentation
Abstract PTU-076 Figure
Results
ConclusionFaecal VOCs are capable of distinguishing IBD from non-inflammatory conditions like IBS and healthy.
Disclosure of Interest
None Declared
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