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We devised a silicon photonic circuit with polarization diversity that consists of polarization splitters and polarization rotators. The splitter is based on a simple directional coupler and the rotator has an off-axis double-core structure. Both devices can be made by using planar fabrication technology and require no complex proceses for the fabrication of three-dimensional structures. We fabricated a polarization-independent wavelength filter based on Si wire waveguides as an application of the polarization diversity. The filter consists of the polarization splitters, the rotators, and a ring resonator. The polarization-dependent loss of the filter is about 1 dB. A 10-Gbps data transmission with scrambled polarization is demonstrated.

Sodium glucose cotransporter 2 inhibitors have attracted attention as they exert antidiabetic and antiobesity effects. In this study, we investigated the effects of tofogliflozin on glucose homeostasis and its metabolic consequences and clarified the underlying molecular mechanisms. C57BL/6 mice were fed normal chow containing tofogliflozin (0.005%) for 20 weeks or a high-fat diet containing tofogliflozin (0.005%) for 8 weeks ad libitum. In addition, the animals were pair-fed in relation to controls to exclude the influence of increased food intake. Tofogliflozin reduced the body weight gain, mainly because of fat mass reduction associated with a diminished adipocyte size. Glucose tolerance and insulin sensitivity were ameliorated. The serum levels of nonesterified fatty acid and ketone bodies were increased and the respiratory quotient was decreased in the tofogliflozin-treated mice, suggesting the acceleration of lipolysis in the white adipose tissue and hepatic β-oxidation. In fact, the phosphorylation of hormone-sensitive lipase and the adipose triglyceride lipase protein levels in the white adipose tissue as well as the gene expressions related to β-oxidation, such as Cpt1α in the liver, were significantly increased. The hepatic triglyceride contents and the expression levels of lipogenic genes were decreased. Pair-fed mice exhibited almost the same results as mice fed an high-fat diet ad libitum. Moreover, a hyperinsulinemic-euglycemic clamp revealed that tofogliflozin improved insulin resistance by increasing glucose uptake, especially in the skeletal muscle, in pair-fed mice. Taken together, these results suggest tofogliflozin ameliorates insulin resistance and obesity by increasing glucose uptake in skeletal muscle and lipolysis in adipose tissue.

We describe an ultrasmall polarization splitter based on a simple directional coupler consisting of silicon wire waveguides. The size is only 7 x 16 microm(2), and the polarization extinction ratio is about 15 dB for a single coupler. A double-coupler structure improves the extinction ratio to over 20 dB. The excess loss is smaller than 0.5 dB for both types of device. In the device, the shape of the high-speed waveform is retained at any angle of polarization. Our polarization splitter represents a first step towards accomplishing an ultrasmall optical circuit with polarization diversity based on silicon wire waveguides.

Abstract. This work proposes a method to control the dominance area of solutions in order to induce appropriate ranking of solutions for the problem at hand, enhance selection, and improve the performance of MOEAs on combinatorial optimization problems. The proposed method can control the degree of expansion or contraction of the dominance area of solutions using a user-defined parameter S. Modifying the dominance area of solutions changes their dominance relation inducing a ranking of solutions that is different to conventional dominance. In this work we use 0/1 multiobjective knapsack problems to analyze the effects on solutions ranking caused by contracting and expanding the dominance area of solutions and its impact on the search performance of a multiobjective optimizer when the number of objectives, the size of the search space, and the complexity of the problems vary. We show that either convergence or diversity can be emphasized by contracting or expanding the dominance area. Also, we show that the optimal value of the area of dominance depends strongly on all factors analyzed here: number of objectives, size of the search space, and complexity of the problems.

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On-chip all-optical switching based on the carrier plasma dispersion in an argon ion (Ar+) implanted photonic crystal (PhC) nanocavity that is connected to input/output waveguides is described. A high dose of Ar+ is introduced, and annealing is used to recrystallize the silicon and thus create dislocation loops at the center of the PhC slab. Dislocation loops enable the fast recombination of the carriers, which allows a fast switching recovery time for PhC switches. The switching window (∼70ps) is three times smaller than that without ion implantation, while the required operating energy remains almost the same (<100fJ).