[reaction: see text] Without the use of hydrophilic cosolvents or phase transfer catalysts, Pd(0)-catalyzed hydrogermylation of alkynes in water provides dienylgermanes efficiently with high stereo- and regioselectivity. The reaction in water proceeds much faster than the reaction under neat conditions. By using an aqueous system, hydrogermylation can be conducted at a low catalyst loading.
A convergent synthesis of a pyrimidine core has been achieved. Treatment of alpha,alpha-dibromo oxime ethers, which are easily derived from the corresponding esters, with a variety of Grignard reagents provides trisubstituted pyrimidines in good yields. This new method offers an easy access to functionalized pyrimidines.
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