The present paper deals with the determinations by means of Ko dama's modification of the colorimetric method of Folin , Cannon and Denis of epinephrine in the suprarenal glands in the rabbits , in which a series of blood sugar determinations was made, a certain amount of blood shed from the carotid artery and finally the glands were taken out , the ani mals being killed by a blow on the neck. The results of the estimations of the glycogen in the liver and muscle in these animals have been previously re ported.1) The present report contains a few cases which were not included in the previous one.It is superfluous to repeat here the methods and procedures used for the experiments cited in this paper.In the main the present results agree with the recent investigationss2)3)4) with the colorimetric method of Suto and Inouye . Two of them were able however to witness a considerable loss of epinephrine after haemorrhage ,, while the depletion of epinephrine (Folin) discovered in the present work was by no means excessive. The degree of reduction listed in the paper of Hara rather coincides with that of us. Further it maybe recalled here that Yo shinaga detected some diminution of epinephrine storage by bleeding about ten years ago, the modification of Ingier and Schmor1 being applied .5) Takahashi determined the epinephrine content of the suprarenals of rabbits immediately, 15, 20 or 40 minutes , 2 or 3 hours after bleeding and 1) Hiroshi Tachi, Tohoku J.
The blood sugar content and the epinephrine discharge after haemor rhage were previously separately studied in non-fastened, non-anaesthetized dogs by two of us;1) 2) the results may be recapitulated as follows: In order to evoke an increase of the blood sugar content a quantity of at least one fourth of the total blood amount must be shed, and the shedding of one third calls forth a significant hyperglycaemia. Double splanchuectomy interferes with the occurrence of hyperglycaemia of a moderate strength, but when a considerable mass of blood is shed, the blood sugar content increases definitely, though only a little, in the bilaterally splanchnectomized dogs. The haemor rhage of one tenth of the total blood quantity acts, on the other hand, to induce invariably a definite acceleration of the epinephrine discharge, and the greater the haemorrhage, the more intensive and longer the acceleration of the epinephrine discharge.Further it is a well substantiated fact that adrenaline exerts an influ ence upon the coagulability of blood.3) The problem of the effect of haemor rhage upon the clotting time of blood was attacked anew by the other of us, 1) Taehi, Tohoku J.
Mantle cell lymphoma (MCL) is currently regarded as one of the most incurable lymphomas, although reliable prognostic indicators are not yet to be defined. In a previous report, it was indicated that most of the patients with immunohistochemically cyclin D1(+)-MCL pursued the lethal clinical course within 7 years, not having achieved complete remission (CR). Recently, a high dose chemoradiotherapy was carried out, this was supported by peripheral blood stem cell transplantation (PBSCT) using the CD34(+)-selection method in a 48-year-old female patient with cyclin D1(+)-MCL. The tumor cells were detected in her peripheral blood despite four courses of combination chemotherapy using CHOP regimen. Soon after the pre-conditioning of total body irradiation (TBI) and high dose melphalan, she received the PBSCT of 1.8 x 10(6)/kg CD34+ cells and showed rapid hematological recovery without life-threatening complications. The patient achieved CR and was alive, without disease, 730 days after PBSCT. Thus, CD34+ selected PBSCT appears to provide further insight into the effective treatment and possible cure of this aggressive disease, i.e. cyclin D1(+)-MCL.
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