Immunoperoxidase methods were used to study ABO(H) blood group antigens and carcinoembryonic antigens in patients with transitional cell carcinoma of the bladder. In our study absence of blood group antigens in cancer tissues was not found to be correlated with histologic grade, stage and survival rate in patients with bladder carcinoma, while it was correlated with subsequent intravesical recurrences. In contrast, the presence of carcinoembryonic antigens in cancer tissues was correlated well with histologic grade, stage and survival rate. Our results suggest that immunoperoxidase detection of blood group antigens could not predict poor survival. In contrast, immunoperoxidase detection of carcinoembryonic antigens is of prognostic value in patients with transitional cell carcinoma of the bladder.
The localization of the testosterone-estradiol-binding globulin (TeBG) in prostate, liver and metastatic lymph node cells of a patient with hormone-independent prostatic carcinoma was studied by the triple-layer indirect immunoperoxidase method using anti-human TeBG antibody. The reaction with anti-human TeBG antibody appeared to be localized in the epithelial cells of the original and metastatic tissues of the prostate, and a weakly positive stain also appeared in parenchymal liver cells. The staining of the epithelial cancer cells with anti-human TeBG antibody was uneven, suggesting that the hormone-independent cancer cell population is heterogeneous as far as the localization of the TeBG is concerned.
A novel window structure referred to as window grown on facets (WGF) is applied to a 10%-95% coated narrow-stripe laser with a wavelength of 780 nm. An aspect ratio of 2 in the beam divergence without a decrease in the differential quantum efficiency is obtained by optimizing the narrow-stripe structure. Highly reliable operation under 70 mW CW at 60°C is attained beyond 4000 hours.
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