occurred in males and 11 (20%) in females. The frequency of age was the type of normal distribution with the highest in the fifth decade. Sixty percent of the metastases resulted from the left hemisphere, because most of the tumor in the dominant hemisphere were given radiotherapy and/or chemotherapy after the decompressive craniectomy. Except two cases, all of them received various operations, and second or third operation was performed to 28 cases of them. There were two interesing cases of metastases through the ventriculo-pleural shunt. Radiotherapy were carried out to 30 cases (57%) and chemotherapy to 5 cases (9%). One year survival of metastatic cases was 25, which was longer than a mean survival time of glioblastoma multiforme. The favered sites of metastases were, in order of frequency, cervical and mediastinal lymph nodes, lung, vertebral and the other bones, and liver. Also in the operative flap and the dural venous system, which were thought to be passages of all remote metastases, there were foci of metastases in 14 cases. It was possible to classify the pathway of metastasis of glioblastoma multiforme by following types; 1) Hematogenous metastasis through blood vessels of primary tumors.2) Hematogenous metastasis through the dural vein invaded by tumor cells.3) Hematogenous and/or lymphogenous metastasis from infiltrative foci in cranium, cranial soft tissues and the other tissues surrounding central nervous system. 4) Spread through cerebro-spinal fluid. 5) Hematogenous metastasis or dissemination via ventricular drainage tube. Type I of metastasis was scarcely present, and type 3 was seen in almost all of operative cases. Metastasis of non-operative cases was seen to be occurred by type 2 or type 4. Type 5 was important, because in future such a type will be increases according as the therapy for malignant glioma would make progress. 34.Classification of Thalamic Tumor
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