Halo application is a standard method for cervical immobilization. However, complications may occur in children because of their thin skull and immature bone. The authors report two cases of odontoid fracture in preschool children treated with a Minerva cast. Two 4-year-old children sustained displaced odontoid fractures in motor vehicle accidents. The fractures were immediately reduced and immobilized using a Minerva cast, followed by the application of a soft collar. By the 1-year follow-up, uneventful bone union had occurred, and the children were able to attend preschool with minimal or no neurologic deficits. The Minerva cast is a classic, inexpensive method of cervical immobilization and is still useful for this kind of fracture. Immediate reduction and immobilization with a Minerva cast is a viable option for displaced odontoid fractures in preschool children.
In animal models of spinal cord injury (SCI), inducible NO (nitric oxide) synthase is expressed in the spinal cord immediately after sustaining SCI. Excessive NO production has cytotoxic effects and induces neuronal apoptosis, causing neural degeneration and neurodysfunction in the spinal cord. Little is known, however, about the relationship between NO x (NO metabolites: nitrite and nitrate) levels in the cerebrospinal fluid (CSF) and neurologic severity or recovery in clinical cases. The objective of the present study was to examine the correlation between CSF NO x levels and neurologic severity or recovery in SCI. Twenty-five patients with incomplete cervical cord injury (CCI) were examined. Eight cases were treated conservatively (non-operated group). Seventeen cases underwent surgical intervention (operated group). NO x levels in the CSF were measured using the Griess method. The severity of the neurologic impairment was assessed using Frankel's classification and the American Spinal Injury Association motor score (ASIA MS). The degree of neurologic recovery was assessed using Frankel's classification and the ASIA motor recovery percentage (MRP). There was no significant difference in the NO x levels between the CCI group (NO x levels: 5.9 ± 0.7 lM) and the 36 control subjects (1 volunteer and 35 patients without neurologic disorders, NO x levels: 4.9 ± 0.3 lM). There was no significant difference in NO x levels and MRP between the non-operated group and the operated group. The NO x levels in total SCI group were significantly correlated with the ASIA MS and MRP. There was a significant correlation between CSF NO x levels and neurologic severity or recovery in incomplete CCI.
There was a significant correlation between CSF [NOx] at the pathologic early subacute stage (approximately 5-14 days) and neurologic severity and recovery in SCI.
In animal models of degenerative lumbar disease, inducible nitric oxide synthase (iNOS) is expressed in macrophages and Schwann cells following compression of the cauda equina. We previously reported that NO metabolites (nitrite plus nitrate: [NOx]) in the cerebrospinal fluid (CSF) correlate with postoperative pain relief in patients with degenerative lumbar disease and with neurologic recovery rate postoperatively or after conservative treatment in patients with spinal cord injury. The objective of the present study was to examine the relationship between [NOx] and neurologic severity, and recovery in degenerative cervical and lumbar diseases. Two hundred fifty-seven cases, including 85 patients with cervical compression myelopathy (CCM), 25 with cervical disc herniation (CDH), 70 with lumbar canal stenosis (LCS), and 77 with lumbar disc herniation (LDH), were examined. The CSF [NOx] was measured using the Griess method. Severity of neurologic impairment and clinical recovery was assessed using the Japanese Orthopedic Association score and Hirabayashi's method. [NOx] in CCM and LCS, but not CDH and LDH groups, was significantly higher than that in controls, and correlated with postoperative recovery rates, but not with preoperative neurologic severity. [NOx] significantly correlated with neurologic recovery following surgery for CCM and LCS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.