We present a new method for the continuous flow production of concentrated hyperpolarized xenon-129 (HP 129Xe) gas from a dilute xenon (Xe) gas mixture with high nuclear spin polarization. A low vapor pressure (i.e., high boiling-point) gas was introduced as an alternative to molecular nitrogen (N2), which is the conventional quenching gas for generating HP 129Xe via Rb-Xe spin-exchange optical-pumping (SEOP). In contrast to the generally used method of extraction by freezing Xe after the SEOP process, the quenching gas separated as a liquid at moderately low temperature so that Xe was maintained in its gaseous state, allowing the continuous delivery of highly polarized concentrated Xe gas. We selected isobutene as the candidate quenching gas and our method was demonstrated experimentally while comparing its performance with N2. Isobutene could be liquefied and removed from the Xe gas mixture using a cold trap, and the concentrated HP 129Xe gas exhibited a significantly enhanced nuclear magnetic resonance (NMR) signal. Although the system requires further optimization depending on the intended purpose, our approach presented here could provide a simple means for performing NMR or magnetic resonance imaging (MRI) measurements continuously using HP 129Xe with improved sensitivity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.