Vancomycin (VCM) is a glycopeptide antibiotic, isolated from Streptomyces orientalis, that is active against methicillin-resistant Staphylococcus aureus (MRSA). However, VCM has severe side effects, such as auditorotoxicity and nephrotoxicity, 1) at dose levels only slightly higher than the effective treatment concentration. Therefore, therapeutic drug monitoring (TDM) is important to administer VCM effectively and safely.
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