DNA strand displacement is an essential reaction in genetic recombination, biological processes, and DNA nanotechnology. In particular, various DNA nanodevices enable complicated calculations. However, it takes time before the output is obtained, so acceleration of DNA strand displacement is required for a rapid-response DNA nanodevice. Herein, DNA strand displacement by using DNA photo-crosslinking to accelerate this displacement is evaluated. The DNA photo-crosslinking of 3-cyanovinylcarbazole ( K) was accelerated at least 20 times, showing a faster DNA strand displacement. The rate of photo-crosslinking is a key factor and the rate of DNA strand displacement is accelerated through ultrafast photo-crosslinking. The rate of DNA strand displacement was regulated by photoirradiation energy.
The cover picture shows DNA strand displacement being accelerated by ultrafast photo‐crosslinking with 3‐cyanovinylcarbazole. The invader strand (red) containing CNVK, which can crosslink to a pyrimidine base in a complementary strand after a few seconds of photoirradiation, can crosslink to the template strand (blue) and push out the passenger strand (green). The rate of photo‐crosslinking is a key factor; the rate of DNA strand displacement can be accelerated by using ultrafast photo‐crosslinking and regulated by photoirradiation energy. More information can be found in the communication by K. Fujimoto et al. on page 1984 in Issue 20, 2017 (DOI: 10.1002/cbic.201700430).
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