The relationship was examined between the tumoricidal effect and the electrical variables of in vivo electrical impulse chemotherapy. Donryu rats subcutaneously inoculated with AH‐109AY hepatocellular carcinomas were given a single high‐voltage electrical impulse of varying voltage and duration, 30 min after an intramuscular injection of 4 mg/kg bleomycin. As the voltage (V) was increased from 0 to 5 kV, the tumoricidal effect (E) increased in proportion to the square of the voltage. As the pulse duration (D) was increased from 2.5 to 5.8 ms, the tumoricidal effect increased in direct proportion to it. Combining these results yielded the formula, E=γV2D, which indicates that tumoricidal efficacy was proportional to the applied electrical energy. When the electrical energy was kept constant while varying the voltage and duration of pulse, the anticancer effect was the same, confirming this relationship for lower energy levels.
A 44-year-old female was admitted to our hospital with a painless tumor in the right breast. A standard radical mastectomy was performed due to the detection of cancer. A histologic examination revealed a solid-tubular carcinoma [Stage I (t1n1mo)]. Following the operation, she was given a prescription for 5-FU (200mg), PSK (3g) and TAM (20mg) to be taken each day.On the 101st day after discharge, she was admitted to our hospital again complaining of epigastralgia. On the gastroendoscopy and the barium enema, a gastric cancer and a colon polyp were detected. A distal partial gastrectomy (R2) and abdominal polypectomy were performed. A histologic examinaiton revealed a signet-ring cell carcinoma [Stage I (H0P0mn0)] in the gastric cancer and a carcinoma of the adenoma in the colon polyp.She recovered well after the operation. Our experience of this case has emphasized the significance that adequately planned examination schedule is vital for detecting the secondary cancers in early stages.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.