This study compares 4 baseline correction methods on the effect of moxifloxacin on the QT/QTc interval: (1) day -1 time-matched baseline electrocardiograms (ECGs), (2) 3 triplicate predose ECGs, (3) 1 triplicate predose ECG, and (4) no baseline correction. Forty-four healthy subjects receive a single dose of moxifloxacin (400 mg), placebo, and 2 doses of an investigational agent in a 4-period crossover fashion. For all 4 methods, the largest mean difference from placebo in the moxifloxacin study-specific QTc is 11.97 to 13.23 ms and occurs at 3 to 4 hours postdose; the lower 90% confidence interval is greater than 5 ms from 2 to 8 hours. The average standard error of the mean is 1.36 ms for 3 triplicate predose ECGs, 1.40 ms for 1 triplicate predose ECG, 1.60 ms for day -1 time-matched baseline ECGs, and 1.65 ms for no baseline correction. Predose baseline methods (3 or 1 triplicate ECGs) are superior to the day -1 time-matched baseline correction or without baseline correction.

Good quality single crystals of organic imidazolium L-Tartrate (IMLT) are grown up from aqueous solution by slow solvent evaporation technique. Various structural parameters and monoclinic crystal structure have been confirmed using powder X-ray diffraction method. The presence of various functional groups has been identified by ATR-FTIR. UV-Vis-NIR spectroscopy has shown more than 60% of optical transparency with the lower UV cutoff at 245nm. The optical band gap value of the material is evaluated to be 4.8 eV. Other optical parameters such as refractive index, optical and electrical conductivity, Urbach energy, extinction coefficient, and optical and electrical susceptibility have been evaluated from transmission spectrum data. The above essential parameters manifest appropriate usage of IMLT as an NLO material. The thermogravimetric analysis indicates high thermal stability of material up to 214°C. Apart from that, the dielectric study at various temperatures confirms decrement of dielectric constant and dielectric loss at higher frequencies. The efficiency of Second Harmonic Generation (SHG) is found to be 3.5 times that of the KDP crystals. A range of analysis suggests suitability and potentiality of IMLT crystal for various optoelectronic applications.

Introduction: Respectful maternity care (RMC) is not only the marker of quality maternity care but also ensures the protection of basic human rights of every child-bearing woman. This paper discusses the assessment of RMC services during the intrapartum period at public health care facilities in Gujarat state. Material and Methods: A cross-sectional research design was used for the study. The data were collected from three different levels of public health facilities such as primary health center (PHC), community health center (CHC), and district hospital (DH) in one of the districts in Gujarat. A standardized tool developed by the United States Agency for International Development based on the RMC charter was used for data collection. A total of 41 pregnant women across three public health facilities were observed during intrapartum care. Findings: Most women experienced disrespectful intrapartum care provided at the public health care facilities; however, at-least two performance standards of the RMC charter were met during intrapartum care at each public health care facility. Comparatively, the PHC demonstrated higher RMC performance compliance than DH and the CHC. Most often violations of RMC standards included beneficiaries were not greeted, privacy not maintained, they were not encouraged to ask questions, and support not provided during labor. Conclusion: Respectful maternity care is evidently not practiced in public health care facilities. Designing comprehensive behavioral training on RMC, especially for primary, secondary, and tertiary care physicians and nursing staff can improve the adaption of RMC standards in respective public health care facilities. Positive experiences of intrapartum care can potentially improve the uptake of maternal care facilities. Further research is needed to understand local contextual factors, social norms, and patient-provider interactions.

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