Abstract:Background: As a tertiary hospital, Tawam Hospital has been dealing with more and more complex pediatric cases. Such cases are often at higher risk of developing Invasive Candida Infections (ICI). Amphotericin B preparations continued to provide the widest coverage for all Candida strains and have been the drug of choice for definitive and empirical therapy in our institute. However, renal complications have always been a concern with this group of antifungals. Numerous studies have reported contradicting results in terms of which Amphotericin B preparation has less renal side effects. Therefore, we are here to report our own experience.
Abstract:Background: Invasive candida infections (ICI) are a growing problem in critically ill patients. Candida species are the most common agent responsible for invasive fungal infections in children. Timely diagnosis and proper selection of antifungal therapy are of paramount importance for a favorable outcome. The increasing rate of non-albicans candida is becoming a real challenge when choosing an empirical antifungal therapy since a large percentage of them are resistant to azoles. This study aims at identifying the most commonly used antifungal agents in our institute and their success measured by the time needed to reach a negative culture (TNC) in cases of candidemia and candiduria
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