Background: The most significant and challenging health issue of the modern era is diabetes mellitus and its complications. Inflammation plays a crucial role in the development and progression of diabetes. Type 2 Diabetes Mellitus patients(T2DM) are at significant risk of developing cardiovascular diseases. High-sensitive CRP (hs-CRP) has become a reliable indicator of low-grade inflammation. Since very little is known regarding the relationship between hs-CRP and T2DM, the goal of this study was to evaluate hs-CRP levels and lipid profile and to study their relationship to cardiovascular problems in Type 2 Diabetes Mellitus patients. Material and Methods: The current study was carried out at Index Medical College and Hospital in Indore. The study group consisted of 70 healthy controls and 70 Type 2 Diabetes Mellitus patients who had been diagnosed following WHO criteria. Serum hs-CRP concentrations as well as the lipid profile (total cholesterol, HDL, and TG) were assessed. SPSS version 26 was used to analyze the data. Results: In comparison to controls, individuals with Type 2 Diabetes Mellitus had significantly higher levels of hs-CRP, with a mean value of 2.49 + 1.15 mg/L (p <0.001).

Background: Interest in the physiological range of androgens in middle-aged men has recently increased since many illnesses, deaths, or male-specific disturbances are linked to androgen deficiency. It is yet unknown how dihydrotestosterone (DHT) levels have changed over time in the Indian population. Aims and Objectives: The purpose of the study was to measure the levels of DHT in males as age. The absence of data on DHT levels in ageing males in the Indian population would allow for comparisons with future studies from other subcontinents. Materials and Methods: In this study, residents of Moradabad, Uttar Pradesh, are the subjects of an observational and comparative case–control study. Results: A total of 210 samples were collected, including 105 diabetic men and 105 controls, samples were divided into each of the three age brackets 30–40 years, 40–50 years, and 50–60 years. Compared to controls, who had a total mean DHT of 446.76 ± 265.31 pg/ml, diabetics’ total mean DHT was lower at 230.66 ± 182.02 pg/ml. The same was seen when diabetic samples and controls were compared by age groups. When age groups of diabetic samples and controls were compared there was no decline with the age group, there was a non-significant association in their comparison. When all of the samples were included, there was a non-significant reduction in DHT levels as the age groups progressed, although a decline was observed. Conclusions: Age-related declines in serum DHT hormone levels occur over time but are not very significant.

Background: Male fertility is affected by the metabolic and hormonal dysregulation brought on by Diabetes Mellitus, a metabolic illness, particularly in the hypothalamus-pituitary testicular axis. However, there is little proof that endocrinopathy causes diabetic men's infertility and low testosterone levels. It is well established that Type 2 Diabetes causes dyslipidemia & obesity by lowering serum testosterone levels. However, there isn't much research on DHT, the most potent androgen, and its relationship to male lipid profiles. Methods:  The study was carried out at Teerthanker Mahaveer Medical College and Research Centre, Moradabad, in the Department of Physiology and Medicine & Department of Physiology Santosh Medical College, Ghaziabad. A total of 210 samples—105 from type 2 diabetics and 105 from controls—were included in the study. Using conventional biochemical techniques, Lipid parameters [HDL, LDL, VLDL &TC], serum DHT, Data analysis was done with SPSS 26. [ trial version]. Results: The levels of serum dihydrotestosterone were significantly lower in diabetic cases than in healthy controls [439.26 ± 257.87pg/ml vs 230.66 ± 182.02pg/ml, p=0.001]. 90 percent of Type 2 diabetics were found to have subnormal levels, as opposed to just 10 percent of controls.

Background A risk factor for cardiovascular disease, particularly vascular disease when linked to Diabetes Mellitus, is the decline of male sex androgens. In recent years, many forms of studies have been conducted to confirm its link. Male hypogonadism is linked to dyslipidemia, visceral obesity, and CVD disorders. Testosterone's role in Type 2 Diabetes has been researched alone or in conjunction with Sex hormone binding globulin. DHT, the most recent androgen to be discovered whose functions are being researched and elaborated upon, hasn't received much attention. Very little research has been conducted in India and Asia that looked at androgens associations with cardiac risk indicators. Methods:  The study was carried out at Teerthanker Mahaveer Medical College and Research Centre's Department of Physiology and Medicine and Santosh Medical College's Department of Physiology in Moradabad and Ghaziabad, respectively. A total of 210 samples, including 105 from type 2 diabetes and 105 from controls, were used in the investigation. Lipid parameters [HDL, LDL, VLDL & TC], serum DHT, and data analysis were performed using the conventional biochemical methods and SPSS 26 (trial version).