Email: Martijn JL Bours* -M.Bours@epid.unimaas.nl; Hilde J Bos -H.Bos@student.unimaas.nl; Jon B Meddings -Jon.Meddings@ualberta.ca; Robert-Jan M Brummer -RJ.Brummer@INTMED.unimaas.nl; Piet A van den Brandt -PA.vandenBrandt@epid.unimaas.nl; Pieter C Dagnelie -Dagnelie@epid.unimaas.nl * Corresponding author Abstract Background: It is well-known that nonsteroidal anti-inflammatory drugs (NSAIDs) can cause damage to the small bowel associated with disruption of mucosal barrier function. In healthy human volunteers, we showed previously that topical administration of adenosine 5'-triphosphate (ATP) by naso-intestinal tube attenuated a rise in small intestinal permeability induced by short-term challenge with the NSAID indomethacin. This finding suggested that ATP may be involved in the preservation of intestinal barrier function. Our current objective was to corroborate the favourable effect of ATP on indomethacin-induced permeability changes in healthy human volunteers when ATP is administered via enteric-coated capsules, which is a more practically feasible mode of administration. Since ATP effects may have been partly mediated through its breakdown to adenosine, effects of encapsulated adenosine were tested also.
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