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The expression of neuropsin mRNA in vivo in mouse skin was examined by in situ hybridization and Northern blotting under stimulated conditions. Two kinds of epidermal stimuli, a topical application of a chemical tumor promoter and incisional wounding, were used. A single topical application of 12-O-tetradecanoyl-phorbol 13-acetate induced epidermal hyperplasia and simultaneously induced an extensive increase in neuropsin mRNA in the suprabasal cells. A full-thickness skin incision also induced a profound increase in neuropsin mRNA in the suprabasal cells surrounding the wound but not in actively proliferating basal cells. The increases in neuropsin mRNA occurred rather late and were limited to the site of drug application or around the incision. Interestingly, neuropsin mRNA was not expressed in the epithelial tongue migrating toward the wound during re-epithelialization. Thus, neuropsin might participate in accelerated epidermal differentiation rather than in the proliferation or migration of keratinocytes in the wound.

Various methods have been reported to correct an inverted nipple. Although a satisfactory outcome has been reported with most techniques, each method carries a drawback inherent in the technique itself, including complicated operative technique, sensory disturbance of the nipple, marked scarring of the nipple areola and other donor regions, destruction of breast function, and incomplete correction. This report describes a simple method for correcting an inverted nipple. It incorporates a new concept of using artificial dermis for tissue augmentation and is performed without sacrificing any donor site and complex design. It was applied to four nipples in two nulliparous cases. For all four corrected inverted nipples, good results were obtained, and there have been no complications. There were no deformities of the nipples or the areolas after this procedure, and the surgical scars were inconspicuous.

We present a simple procedure for monitoring a free jejunal flap. Peristalsis is assessed by echography every 4 h during the first 3 postoperative days and once a day during the following 4 days. When peristalsis is not seen, it is stimulated by pushing on the skin and is again observed. This method has been used in five patients, and peristalsis was detected in all five. This method is simple, inexpensive, and noninvasive; thus it is a very effective technique for free jejunal flap monitoring

An 82-year-old man presented with multiple adenolymphomas of the parotid and neck (Warthin's tumours) with a coexistent pleomorphic adenoma. Two Warthin's tumours were within the parotid gland as was the adenoma, and four were in the neck region. The patient made an uneventful recovery from excision of the neck tumours and superficial parotidectomy. We know of no similar previous case, and emphasise the importance of confirming the histological diagnosis so that the correct treatment may be planned.

these results, we have performed surgery first when the combined therapy has been applied if necessary. At the resection of the lesion, we make efforts to preserve pharyngeal mucosa as much as possible with the margin of about 2 cm. Primary closure of the pharynx is performed, when the width of the mucosa is more than 2-3 cm, and the reconstruction by a forearm free skin flap, when less than it. In the case of circumferential mucosal defect, a free jejunum is used. Out of 138 PSC, 94 (68.1%) was possible to close the pharynx primarily. The second primary malignancies were found in 47 patients (18.4%) and the strict follow up is important especially for carcinoma of the esophagus, the mesopharynx or the lung, which have common risk factors of drinking or smoking.

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