A series of 7-aminothiadiazolylcephalosporins having a 1-(substituted)-1H-imidazo [4,5-b]pyridinium group at the C-3' position of the cephem nucleus were synthesized and evaluated-yl]methyl-3-cephem-4-carboxylate sulfate (S-3578) showed extremely potent broad spectrum activity against both Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria including Pseudomonas aeruginosa, and good water solubility.
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