Background: ApoE is a genetic risk factor for Alzheimer disease. Results: As compared with apoE2/3, apoE4 failed to inhibit the conversion of A protofibrils to fibrils in vitro. Intracerebral injection of A protofibrils with apoE3 attenuated A deposition, whereas apoE4 did not. Conclusion: ApoE3, not apoE4, impedes -amyloid formation. Significance: Interaction between A and apoE is a critical determinant of -amyloid formation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.