[reaction: see structure] The antioxidant activity of curcumin (1, 7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) was determined by inhibition of controlled initiation of styrene oxidation. Synthetic nonphenolic curcuminoids exhibited no antioxidant activity; therefore, curcumin is a classical phenolic chain-breaking antioxidant, donating H atoms from the phenolic groups not the CH(2) group as has been suggested (Jovanovic et al. J. Am. Chem. Soc. 1999, 121, 9677). The antioxidant activities of o-methoxyphenols are decreased in hydrogen bond accepting media.

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Summary:gated in patients receiving BMT and PBSCT. [5][6][7][8][9][10][11] A strong inverse correlation between serum granulocyte colony-stimulating factor (G-CSF) level and absolute neuRecently, the ligand for c-mpl has been cloned and initial studies have shown it to be the platelet regulatory trophil count has been demonstrated, 5-9 which suggests that G-CSF plays a critical role in the reconstitution of myeloid factor, thrombopoietin (TPO). To elucidate the role of TPO in the reconstitution of megakaryopoiesis and lineage progenitors after stem cell transplantation. However, of the growth factors studied, including interleukin-3 platelet production after stem cell transplantation, we measured serum TPO levels in nine patients undergoing (IL-3), interleukin-6 (IL-6) and leukemia inhibitory factor (LIF), none have been demonstrated to correlate with plateautologous peripheral blood stem cell transplantation (PBSCT) and in healthy volunteers. Serum TPO levels let recovery after stem cell transplantation. 6,9-11 A possible exception was reported by Testa et al 11 who showed that significantly correlated with the degree of peripheral thrombocytopenia and a strong inverse correlation peak IL-6 levels are directly correlated with the peak of platelet recovery. between serum TPO level and platelet count was observed (r = −0.700, P Ͻ 0.001). Serum TPO levels Recently, the ligand for c-mpl has been cloned; in vitro and in vivo studies have shown that it stimulates both began to rise as the platelet count decreased after chemotherapy. TPO levels peaked at over 25.00 megakaryocytopoiesis and platelet production, suggesting that it is the long-sought platelet regulatory factor, thromfmoles/ml between days 0 and 10; TPO levels then decreased gradually as the platelet count began to rise.bopoietin (TPO) itself. [12][13][14][15] To elucidate the role of TPO in megakaryopoiesis and platelet recovery after stem cell One patient with multiple myeloma received purified CD34 + peripheral blood stem cells. No difference was transplantation, we measured serum TPO levels in patients undergoing autologous PBSCT using a recently established observed in the kinetics of serum TPO levels between unfractionated and purified PBSCT. These observations sensitive sandwich enzyme-linked immunosorbent assay (ELISA). 16 suggest that TPO plays a critical role in the reconstitution of megakaryopoiesis and platelet production after PBSCT.

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