In contrast with other antihypertensive drugs, olmesartan may uniquely increase urinary ACE2 level, which could potentially offer additional renoprotective effects.

RAS blockade decreases adipocyte size without change in epididymal %fat pads accompanied by improvement in insulin sensitivity.

[1] The seasonal changes in evapotranspiration over a hill evergreen forest in northern Thailand (18°48 0 N, 98°54 0 E), in the Asian monsoon region, were simulated using a multilayer model and the boundary conditions above the canopy. The simulation considered the uncertainty in the leaf area index (LAI) and physiological parameters for both photosynthesis and stomatal conductance models. The parameters were based on the estimated LAI and determined by referring to the measured net photosynthesis rate and stomatal conductance for a single leaf. The simulated cumulative evapotranspiration and rainfall interception agreed with the values obtained from the water budget within these uncertainties. The sensitivity of these limits to both evaporation and transpiration was also investigated. The simulated transpiration peaked in the late dry season. The latent heat flux obtained with the eddy correlation technique showed that the forest continued to transpire in the late dry season. The heat pulse velocities also showed a peak in water use by individual trees in the late dry season. These results counter the view that evapotranspiration declines in the dry season, as has been reported previously for an evergreen forest and other vegetation in Thailand. The transpiration peak was thought to depend on the reduced wetness of the canopy, and the consequent lack of evaporation from it, and on the fact that there was little decline in stomatal conductance, even in the driest conditions.

No abstract

Soil respiration and soil carbon dioxide (CO 2 ) concentration were investigated in a tropical monsoon forest in northern Thailand, from 1998 to 2000. Soil respiration was relatively high during the rainy season and low during the dry season, although interannual fluctuations were large. Soil moisture was widely different between the dry and wet seasons, while soil temperature changed little throughout the year. As a result, the rate of soil respiration is determined predominantly by soil moisture, not by soil temperature. The roughly estimated annual soil respiration rate was 2560 g C m Ϫ2 year Ϫ1 . The soil CO 2 concentration also increased in the rainy season and decreased in the dry season, and showed clearer seasonality than soil respiration did.

No abstract

The aim of this study was to compare the effects of an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II receptor (AT) antagonist on insulin resistance, especially on muscle fiber composition in fructose-induced insulin-resistant and hypertensive rats. Six-week-old male SpragueDawley rats were fed either normal rat chow (control) or a fructose-rich diet (FFR). For the last two weeks of a six-week period of either diet, the rats were treated with gum arabic solution as a vehicle (control or FFR), angiotensin-converting enzyme inhibitor (FFR؉ACE), temocapril (1 mg/kg/ day) or an angiotensin II receptor antagonist (FFR؉AT), CS-866 (0.3 mg/kg/day), by gavage, and then the euglycemic hyperinsulinemic glucose clamp technique was performed to evaluate insulin sensitivity. At the end of the glucose clamp, the soleus muscle was dissected for determination of the muscle fiber composition by ATPase methods. Blood pressure at the glucose clamp in the FFR group was significantly higher than that of the control group, and both temocapril and CS-866 significantly lowered the blood pressure of the FFR group. The average rate of glucose infusion during the glucose clamp, as a measure of insulin sensitivity (M value), was significantly lower in the FFR rats compared to the controls (15.4 ؎ 0.4, 10.9 ؎ 0.6 mg/kg/min, for control and FFR, respectively, P < .01). Both temocapril and CS-866 partially improved the M values compared to FFR (13.2 ؎ 0.7, 12.8 ؎ 0.5 mg/kg/min, for FFR؉ACE, FFR؉AT, respectively, P < .01 compared with FFR, P < .05 compared with control). The composite ratio of type I fibers of the soleus muscle was decreased significantly in the FFR rats compared with the controls (82% ؎ 2%, 75% ؎ 2%, for control and FFR, respectively, P < .01), and both temocapril and CS-866 restored a composite ratio of type I fibers to the same level as that of the controls (81% ؎ 1%, 80% ؎ 1% for FFR؉ACE and FFR؉AT, respectively). The M value was significantly correlated with the composition of type I and type II fibers. These results suggest that the fiber composition of skeletal muscle is correlated to insulin resistance, and that both ACE inhibitors and AT antagonists may modulate the muscle fiber composition in a hypertensive and insulin-resistant animal model, fructose-fed rats, to the same extent. Am J Hypertens 2000;13:290 -297

This study was designed to investigate the effects of angiotensin II (AII) receptor antagonist and angiotensin converting enzyme (ACE) inhibitor on insulin resistance, and the mechanism by which ACE inhibitor improves insulin-dependent glucose uptake (insulin sensitivity) in an insulin-resistant hypertensive rat model (fructose-fed rats, FFR) and in essential hypertensives (EHT). Male Sprague-Dawley rats were fed on fructose-rich or standard chow for 4 weeks and treated either with 10 mg/kg/day of delapril (n = 8), 1 mg/kg/day of TCV-116 (AII receptor antagonist; n = 13), or vehicle (n = 9) for the latter 2 weeks. Steady-state plasma glucose (SSPG) was measured with the subjects in the conscious state; simultaneously, we infused insulin (2.5 mU/kg/min) and glucose (8 mg/kg/min) to determine insulin sensitivity in each group. Thirteen EHT were hospitalized and the 2-h euglycemic hyperinsulinemic glucose clamp (GC) method was performed in a fasting condition before and after 2 weeks' administration of TCV-116 (8 mg/day) in 7 EHT and of delapril (120 mg/day) in 6 EHT. Insulin sensitivity was evaluated as M-value calculated from the infusion rate of glucose. Mean blood pressure (MBP) was higher in FFR (137.7 +/- 73.8 mm Hg, P < .05) compared to controls (120.8 +/- 2.7 mm Hg), and was lower in both the delapril (108.1 +/- 6.3 mm Hg, P < .05) and TCV-116 (112.8 +/- 4.3 mm Hg, P < .05) groups than in FFR.(ABSTRACT TRUNCATED AT 250 WORDS)