Donepezil may effectively and safely improve overall functioning of DS patients with severe cognitive impairment.

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The subjects were 98 children with an average age of 5.8 years. The frequent seizures were categorized into the following three modes: (1) seizures occur more than five times a day;(2) 1-4 seizures occur every day for one week or more; (3) 1-4 seizures a day occur weekly for one month or more. The incidence of each mode was as follows: (1) 15.3%; (2) 16.3%;(3) 173% (1) t (2) 43.9%; etc. We observed frequently the cases of tonicclonic seizures in mode (l), infantile spasms (IS) in mode (2), simple partial seizures (SPS) in mode (3), and minor seizures, IS, and Lennox-Gastaut syndrome (LCS) in mode (1) t (2). Abnormal CT findings were observed in 37.8%. Of all the patients, 33.7% indicated a developmental quotient (DQ) or intelligence quotient (IQ) above 80, and 31.6% showed a DQ or IQ under 30. Of 96 patients followed for the past one year or more, 32.3%, consisting mainly of the cases with absence seizures and IS, had been seizure-free for at least one year; 60.4%including the cases with LCS, SPS, etc., still had seizures.(Acta Paediatr Jpn 1989; 3 1 : 237 -244)