Intracerebral hemorrhage (ICH) represents cerebral parenchymal bleeding that may also extend into ventricular, and rarely, subarachnoid space. As a stroke subtype, it is associated with poor neurological outcome as well as high mortality. The worldwide incidence of ICH ranges from 10 to 20 cases per 100,000 population and increases with age. Different risk factors can cause ICH: hypertension (the main and the most common risk factor), cerebral amyloid angiopathy, previous use of anticoagulant therapy, excessive use of alcohol, and also other risk factors such as serum cholesterol levels and some genetic factors. Its clinical presentation usually consist of a decreased level of consciousness with headache and vomiting (in patients with a large hematoma), and depending on localization some specific neurological signs could be present: contralateral sensory-motor deficits of varying severity, aphasia, neglect, gaze deviation, hemianopsia, abnormalities of gaze, cranial-nerve abnormalities, as well as ataxia, nystagmus, and dysmetria.Emergency diagnosis and management in neurological intensive care, or stroke units, with hypertension treatment, administration of haemostatic agents and general therapeutic measures for critically ill neurological patients may positively influence the outcome. Nevertheless, a larger number of randomized controlled studies are needed to answer several important questions, including how to treat hypertension, which haemostatic agent to use, as well as determining place and time of surgical treatment. LJILJANA BESLA]-BUMBA[IREVI] VI[NJA PA\EN DEJANA R. JOVANOVI] MAJA STEFANOVI]-BUDIMKI]
A case of spinal cord glioblastoma multiforme with intracranial dissemination is reported. A 23-year -old female was admitted to a local hospital complaining of lumbago. Myelography revealed an in tramedullary thoracic tumor. The tumor was partially removed through a laminectomy at Th 11-L1. The histological diagnosis was glioblastoma multiforme, and focal irradiation (total 50 Gy) was given. Eight months after the operation, symptoms of increased intracranial pressure appeared. Computed tomographic (CT) scans showed marked hydrocephalus, and multiple tumors at anterior horns of bilateral lateral ventricles. A ventriculoperitoneal shunt and an Ommaya reservoir into the left lateral ventricle were emplaced. Three months later, she was transferred to our hospital. CT scans showed enhanced lesions in the fourth ventricle, anterior horn of the left lateral ventricle, sep tum pellucidum, and pituitary gland. Suboccipital craniectomy was performed, and the mass around the fourth ventricle was partially removed. Histological examination of the tumor specimens showed glioblastoma multiforme. Postoperatively, she received whole brain irradiation (total 50 Gy), and intrathecal injection of β-interferon via the Ommaya reservoir. However, she died of respira tory insufficiency. It is considered that the spinal cord glioblastoma multiforme disseminated into the intracranial space.
SummaryThe risk of thrombosis in type I congenital plasminogen (PLG) deficiency has been suggested, but is still not confirmed. We studied 40 members of two unrelated families with this disease, and found that 21 were heterozygotes of type I congenital PLG deficiency. Three of them had thrombosis, but the other 18 had no thrombosis. The percentages of family members with no history of thrombosis up to a given age among subjects with type I congenital PLG deficiency and healthy controls were analyzed by the Kaplan-Meier method. No significant difference between the two groups was observed by the generalized Wilcoxon test (p = 0.23). These results suggest that there is no significant correlation between type I congenital PLG deficiency and thrombosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.