IntroductionDrug-drug interactions (DDIs) are defined as two or more drugs interacting in such a manner that the effectiveness or toxicity of one or more drugs is altered. Patients with cardiovascular disorders are at higher risk for DDIs because of the types and number of drugs they receive. The aim of the present study was to assess the prevalence of DDIs in patients admitted to the cardiology department of a hospital in Morocco.MethodsA prospective observational study from June 2016 to September 2016 was carried out in the cardiology department of a hospital in Morocco. Those patients who were taking at least two drugs and had a hospital stay of at least 48 hours were included in the study. The medications of the patients were analysed for possible interactions. All the prescriptions of the study population were screened for drug-drug interactions using a computerized DDI database system (Theriaque®).ResultsDuring the study period, 138 patients were included; 360 interactions were detected among 94 patients, with an average number of drugs taken of 5.2. The prevalence of DDIs was estimated at 68.11%, the most common of which concerned Kardegic/Plavix (12.22%), Kardegic/Heparin (8.33%), and Lasilix/Spironolactone (5.83%). Among the 726 prescribed drugs, (372 [51.24%]) were drugs of the cardiovascular system, followed by blood and hematopoietic organ drugs (288 [39.67%]) according to the Anatomical Therapeutic Chemical Classification codes. These interactions were categorized on the basis of level of severity: interactions with major severity accounted for 11.11% (40) of the total DDIs while those with moderate and minor severity accounted for 37.22% (134) and 51.66% (186), respectively.ConclusionThis study reports the prevalence of DDIs in patients admitted to the cardiology department of a hospital in Morocco. This study shows that DDIs are frequent among hospitalized cardiac patients and highlights the need to screen prescriptions of cardiovascular patients for possible DDIs, as this helps in their detection and prevention.Pan African Medical Journal – ISSN: 1937- 8688 (www.panafrican-med-journal.com)Published in partnership with the African Field Epidemiology Network (AFENET). (www.afenet.net)Pan African Medical Journal – ISSN: 1937- 8688 (www.panafrican-med-journal.com)Published in partnership with the African Field Epidemiology Network (AFENET). (www.afenet.net)

Les anticoagulants oraux directs ont montré leur efficacité pour la prévention et le traitement des événements thromboemboliques veineux et la prévention des accidents vasculaires cérébraux dans la fibrillation atriale. Ils exposent cependant à des complications hémorragiques à risque de conséquences létales ou fonctionnelles très sévères dont la prise en charge reste incertaine. Ce sont des situations où il est indispensable d’agir rapidement et de prendre en charge le patient en neutralisant l’effet anticoagulant à l’aide d’un antidote spécifique ou avec des concentrés de complexe prothrombinique non activés ou activés.

La carbamazépine est un anticonvulsivant couramment utilisé. Son intoxication est rarement décrite dans la population pédiatrique. Nous rapportons le cas d’une jeune fille de 11 ans qui avait développé un coma du a une surdose de carbamazépine.

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Background: Despite the many efforts made in the field of endoscope treatment procedures, the risk of infection remains topical. Methods: We conducted an evaluation audit of the manual cleaning procedure applied to flexible endoscopes at the Gastroenterology II department of the Mohamed V Military Instruction Hospital in Rabat. For this, we used a ready-to-use test for detecting ATP according to a bioluminescence reaction. Results: Biological control of the internal canal of the endoscopes used showed that the cleaning was not in conformity with the target value in 62% of the cases. External biological control was non-compliant in 54% of the cases. Conclusion: Compliance with the basic rules of hospital hygiene, the application of rigorous cleaning and disinfection procedures and the orientation towards automated endoscope disinfection systems are essential elements in the prevention and fight against post-endoscopic infections.