Background Dipyrone is a non-narcotic analgesic/antipyretic widely used in some countries but prohibited in others due to suspected risk of agranulocytosis. The primary goal of this study was to evaluate hematological alterations in healthy adult volunteers after treatment with dipyrone. Methods The study enrolled 30 healthy volunteers of both genders, aged 19-37 years. They received tablets containing 500 mg of dipyrone sodium to be used four times daily for 7 consecutive days. Before the first administration, arterial pressure was measured and blood was collected in order to evaluate hematological baseline parameters. On the 8th day after the beginning of treatment, the volunteers had their blood pressure assessed once more and underwent a second blood draw. Total and specific leukocyte counts, creatinine, urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), erythrocytes, and platelets were quantitatively determined. Results No statistically significant difference was observed among total or specific leukocyte counts. Number of platelets, erythrocytes, hemoglobin, and hematocrit decreased after treatment. Diastolic pressure, mean arterial pressure (MAP), and urea concentration declined, while creatinine, AST, and ALT showed no significant alterations. It is noteworthy that, even for parameters that showed statistically significant changes, the highest and lowest values remained within the normal ranges. Conclusions Although dipyrone has historically been associated with agranulocytosis, leukocyte counts remained practically unchanged after oral administration of dipyrone. On the other hand, the present study adds evidence that dipyrone is able to produce statistically relevant decrease in number of platelets, erythrocytes, hemoglobin, and hematocrit in healthy adults, even after short-term treatment.
A intoxicação exógena é resultado dos efeitos nocivos da interação de uma substância química com o organismo. É considerada um problema de saúde pública, pois aumenta a morbidade e a mortalidade. O objetivo desse estudo foi caracterizar o perfil epidemiológico das intoxicações exógenas na cidade de Juiz de Fora - MG. Foi realizado um estudo retrospectivo, transversal e descritivo com dados oriundos de registros de casos ocorridos entre 1º de janeiro de 2013 a 1º de janeiro de 2014. As informações utilizadas foram consultadas em prontuários médicos e resultados de exames toxicológicos, sendo as variáveis contínuas descritas por média e desvio padrão. A associação entre sexo, faixa etária e tipo de intoxicação foi analisada por teste de Qui-quadrado, nível de significância 5%. Foram incluídos 154 prontuários. A idade média foi de 25 anos, com prevalência do sexo masculino (57%) e a letalidade de 4%. Os medicamentos constituíram as principais causas de intoxicações (42%). Em menores de 5 anos e em mulheres as medicações predominaram dentre as formas de intoxicações (p<0.01). Os resultados sugeriram que o perfil epidemiológico das intoxicações exógenas foi semelhante ao padrão nacional. Os dados avaliados indicaram que as intoxicações foram predominantemente para o sexo masculino e por meio de benzodiazepínicos, sendo a idade média de 25 anos dos indivíduos acometidos. As subnotificações e dados incompletos em prontuários dificultaram a avaliação completa acerca do assunto.
BACKGROUND AND OBJECTIVES:The study's objective was to present a case of diffuse chronic pain with 36 months of development, associated with recurrent oral aphthous ulcers and glossitis, highlighting the importance of the wide differential diagnosis and the possibility of vitamin B12 deficiency as a cause. CASE REPORT: Male patient, 39 years-old, white, reported diffuse pain predominantly in the cervical, thoracic, abdominal, thighs and left knee regions, besides the presence of frequent oral aphtae, lasting more than 5 days, multiple and painful, predominantly on the tongue, for 6 months. The condition was attributed to Behçet's disease, but there was complete and permanent remission after treatment with vitamin B12. CONCLUSION: It's important to insert vitamin B12 deficiency for differential diagnosis in chronic pain scenarios.
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