synopsisThe circular dichroism (CI)) spectra of the four usual deoxymo~ioiiucleosides, all sixt e e i i deoxydinucleotides, and a number of trinucleotides have been measured. The dinier spectra are quite different from the sum of the spectra of their constituent monomers. This indicates the presence of base-stacked conformations analogous to those found for ribonucleoside diphosphates. The CD spectra of several deoxytrinucleotide diphosphates and single-strand f l DNA can be calculated fairly well by using a semiempirical nearest-neighbor approach. There is little or no effect of terminal phosphate or of salt concentration 011 the optical properties of most deoxy oligomers. The possibilit,y of simultaneous analysis of mixtures of deoxypurine or deoxypyrimidine sequence isomers has been examined. Thw seems to be a viable approach for the analysis of purine runs but cannot promise much siiccess for pyrimidine runs.
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