Background: Ocular melanoma is a disorder that is rarely found but is deadly. Four tissues in the eye that can be attacked by melanoma include the uveal tract, conjunctiva, eyelids, and orbit. Uveal melanoma is the most common case, while melanoma conjunctiva is very rare. Objective: This study aimed to investigate the effect of giving genistein on cyclin D1 expression in malignant melanoma. Methods: When confluent, CRL1872 malignant melanoma cells will be divided into treatment groups, the group giving genistein dose 25 μM, the group giving genistein a dose of 50 μM, and the group giving genistein a dose of 100 μM. Cyclin D1 analysis was measured by immunofluorescence using confocal laser scan microscopy. Results: There was a significant increase in the expression of cyclin D1, in the group given genistein 25 μM and 50 μM (p < 0.05). For the administration of the genistein dose of 100 μM, cyclin D1 expression decreased significantly compared to the control group (p < 0.05). Conclusion: It was concluded that genistein had a biphasic effect on cyclin D1 expression in malignant melanoma cells. Thus, genistein at the right dose can be a treatment of malignant melanoma.
Background: Cataract is one of the leading cause of blindness in Indonesia and worldwide. Meanwhile the ability to carry out cataract surgery was not balanced by the increasing of cataract backlog of ± 70,000 per year. In addition to increase the number of cataract operations, it is very important to maintain the quality of surgery results by auditing the result of surgery. This study aims to evaluate post-operative visual acuity in social services organized by the Cataract Blindness Prevention Section of IOA Malang Branch in 2015-2017.Methods: This study is a retrospective study based on medical record data of cataract patients underwent cataract surgery at a social service organized by the Cataract Blindness Prevention Section of IOA Malang Branch in January 2015 - December 2017 period. Data collected included demographic data, preoperative and postoperative visual acuity, type cataract surgery, and intraoperative complications.Results: Cataract surgery carried out from 2015-2017 was 1,662 surgeries with 965 male patients (58.06%). Visual acuity before surgery was 1/300 in 583 patients (35.08%). The most cataract surgery procedure performed was SICS (60.17%). Vitreous prolapse was the most common complication found. There was a significant association between age and type of cataract surgery, with postoperative vision (p <0.05, α = 5%). From the analysis, the progress of post-operative visual acuity was found in 85.93% of patients and the results were significant (p <0.05, α = 5%).Conclusions: Cataract surgery may provide significant visual improvement that elevates vision and quality of life for patients.
Background: The number of children's use of gadgets during the COVID-19 pandemic has increased due to the quarantine policy by the government so it has an impact on children's emotional problems. Objective: To determine the relationship between the use of gadgets during the COVID-19 pandemic on children's emotional problems based on the duration of use and ownership of gadgets. Methods: This study used an observational analytic design with a cross-sectional method. The research instrument used an online questionnaire. The sampling method used is simple random sampling. The independent variable is the duration of gadget use and gadget ownership, while the dependent variable is the child's emotional problem. The duration of gadget use is categorized into less than 2 hours and more than 2 hours per day. Ownership of gadgets is categorized as self-owned or not. Emotional problems were categorized by severity (none, mild, severe). Data analysis with Mann-Whitney test using SPSS 25. Results: The number of respondents was 116 children, 13 men (9,56%), and 123 women (91,44%), aged 6-12 years 13 people (9,56%) and 13-18 years old 123 people (91,44%), have their own gadget 2 people (1,5%) and do not have a gadget 134 people (98,5%), the duration of using gadgets is less than 2 hours per day 28 people (20,6%) and more than 2 hours per day 108 people (79,4%). Based on the Mann-Whitney test, there is a relationship between the duration of using gadgets and the level of children's emotional problems (p = 0,017), while gadget ownership is not associated with children's emotional problems (p = 0,431). Conclusion: Regulation is needed to limit the duration of gadget use during the COVID-19 pandemic to prevent children's emotional problems.
Latar Belakang : COVID-19 merupakan masalah kesehatan yang dinyatakan sebagai pandemi oleh WHO. Beberapa penelitian melaporkan tentang hubungan SARS-CoV-2 dengan kelainan pada mata. Pada era pandemi, pengelolaan pasien sakit mata harus hati-hati untuk mencegah penularan petugas medis. Laporan kasus ini menyajikan pengelolaan perforasi kornea pasien terkonfirmasi COVID-19. Metode : Diagnosis ditegakkan berdasarkan anamnesis, pemeriksaan fisik dan oftalmologi dengan pemeriksaan penunjang lainnya. Laporan Kasus : Perempuan berusia 54 tahun dirujuk dengan keluhan keluar darah pada mata kiri sejak 17 jam sebelum sampai RS. Keluhan batuk atau demam 14 hari sebelumnya disangkal. Pada pemeriksaan oftalmologi didapatkan perforasi kornea mata kiri disertai prolaps isi bola mata (iris, vitreus dan choroid). Pada pemeriksaan penunjang didapatkan foto rontgen thorax normal, rapid test covid-19 reaktif dan hasil positif pada PCR dari swab nasofaring. Seluruh staf medis menggunakan alat pelindung diri (APD) tingkat tiga dalam melakukan pemeriksaan fisik maupun penunjang. Dari hasil anamnesis pemeriksaan fisik dan penunjang, pasien didiagnosis dengan perforasi kornea spontan mata kiri dan terkonfirmasi COVID-19. Pasien direncanakan untuk eviserasi mata kiri dengan anestesi umum dan saat tindakan operator dan seluruh staf ruang operasi menggunakan alat pelindung diri (APD) tingkat tiga. Setelah operasi dilakukan, pasien kemudian dirawat di ruang isolasi khusus COVID-19. Swab nasofaring dilakukan ulang sehari setelah operasi dan keesokan harinya. Dua hari setelah operasi, pasien dipulangkan dan isolasi mandiri di rumah Kesimpulan: Laporan kasus ini menunjukkan manajemen perforasi kornea pada pasien terkonfirmasi COVID-19 yang dilakukan sesuai alur khusus termasuk pada pemeriksaan fisik dan penunjang, penegakkan diagnosis oftalmologi dan COVID-19, prosedur pembedahan dan perawatan pasca operasi. Kata Kunci : SARS-CoV-2, Perforasi Kornea, APD, PCR, Eviscerasi Introduction: Corona-Virus-Disease-2019 (COVID-19) is an important health problem that was defined as a pandemic by the World Health Organization (WHO). There are few reports on the association of SARS-CoV-2 with ocular abnormalities. In the pandemic era, management of ocular patients should be more careful to prevent transmission to medical staff. This report presenting the management of corneal perforation in confirmed COVID-19 patients. Method: The diagnosis was established based on history taking, physical and ophthalmology examination with other ancillary tests. Case Report : 54-year-old female patient referred with complaints of left eye bleeding since 17 hours ago. This patient never complaint about cough or fever 14 days before admission. From the ancillary test (complete blood count and chest x-ray are within normal limit, reactive rapid test for COVID-19, positive result of PCR nasopharynx). The patient was diagnosed with spontaneous corneal perforation on the left eye with COVID-19 confirmed. The evisceration procedure with general anesthesia was performed with exceptional precaution. Operator and all operating room staff wear the 3rd level of personal protective equipment (PPE). The surgery was successfully done and the patient then hospitalized in the COVID-19 isolated room. Nasopharynx swab performs the day after surgery and the next day after the first swab. Two days after surgery, the patient was discharged and followed by a self-isolation procedure. Conclusion: This case report presenting corneal perforation management in confirmed COVID-19 patients should be performed under a firm scheme including physical and ophthalmological examinations, ophthalmology and COVID-19 diagnosis enforcement, ancillary test, surgery procedure, post-operative care and also PPE utilization. Keyword : SARS-CoV-2, Corneal Perforation, 3rd level PPE, PCR, Evisceration
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