These data demonstrate that structured prenatal exercise reduces the risk of having a large newborn without a change in the risk of having a small newborn.
Summary SUBJECTS A N D METHODSThe differences in the immediate (30 sec or 1 min) and late (5 min) ventilatory response to high and low Oz have not been SUBJECTS quantitated in preterm infants and adult subjects using the sameWe compared the results obtained in nine "healthy" preternl methods. It was thought that these differences might explain the infants studied during the first days of life with those of paradoxical ventilatory response to COz at various O2 concentrations in preterm infants (12). Thus, 9 preterm infants and 10 adult healthy adult subjects studied at a mean age (+SE) of 27 + 3 yr. subjects were given 21% Oz to breathe and then 100 or 15% Oz for Infants had a mean gestational age (+SE) of 33.5 + 0.5 weeks and 5 min each. Adults also breathed 15% Oz before 100% Oz or 12% mean birth weight of 1490 + 80 g. Adult subjects had a mean Oz in order to make their resting arterial POz more comparable weight of 65 + 5 kg.to those of infants breathing 21% Oz. The ventilatory response to 100% 0 2 was the same in preterm infants and adult subjects, but METHODS the late response to 15% Oz remained paradoxical, ventilation decreasing at by 18% in infants and increasing by 19% in The system to measure ventilation has been described previadults. The authors conclude: 1) the traditional concept of the o u s '~ ('7 9, lo). in we used a and screen ventilatory response to 100% oz being different in infants and flowmeter to measure respiratory minute volume and alveolar adult subjects is false; 2) the notion that the response to low Oz is gases' We eliminated valves and reduced dead 'pace using a paradoxical in infants is correct; and 3) the data do not explain constant background flow which was electrically balanced to an why the to coz under various background concentrations artificial zero. The infant breathed through the nostril adapters of Oz in infants is the reverse of that in adult subjects, but the and added Or substracted (inspiration) the depressed ventilatory response to hypoxia in infants may justify, background flow. The flow signal was integrated at least in part, their flatter response to COz during low Oz give volume. breathing.Breath to breath POz and PCOz was monitored as outlined elsewhere (12). In adults, a similar system was used with the following differences: I) the background flow was 30 liter/min Speculation instead of 2.7 liter/min; 2) a Fleisch pneumotach no. 4 was used The findings suggest that the response of preterm infants to instead of the Monel screen flowmeter; and 3) a mouthpiece high and low 0 2 per se is not the cause of the paradoxical response replaced the nostril adapters. to COz under various background concentrations of Oz. If it were, Infants were studied on the Ohio Neonatal Intensive Care Unit it would be expected that the response to low and high Oz would shortly after a feed. Abdominal skin temperature was kept at 36.5 differ in infants and adults. This was true for hypoxia only, the + 0.03OC. Xylocaine ointment was used to anesthetize the skin response to hyperoxia bein...
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