Implantation of a biodegradable, porous collagen matrix in the subconjunctival space offers the potential for a new means of avoiding early scar formation and maintaining long-term IOP control by creating a loosely structured filtering bleb.
OloGen successfully serves as a 3-dimensional scaffold for cell migration and proliferation, and can prevent failure by maintaining the size of the bleb in the presence of a large wound defect. It might also be successful at repairing postoperative bleb leaks.
We reviewed the charts of 18 patients 20 glaucomatous eyes) who had not used pilocarpine prior to undergoing trabeculectomy combined with or performed later with posterior chamber lens implantation. We then compared postoperative results and complications in these patients with those in 35 other patients (40 glaucomatous eyes) in two age- and stage-matched groups who had used pilocarpine prior to undergoing the same procedures. All patients had a minimum follow-up of 6 months. There was no significant difference between these groups in terms of postoperative intraocular pressure and required glaucoma medications. However, in the pilocarpine-treated groups, there was a significantly higher incidence of complications, especially intraocular lens capture (P<0.05), and of worse visual outcomes (P<0.01).
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