The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
The direct action of adrenalin upon the blood-vessels of the heart has hitherto been observed only upon the lower animals. Two classes of experiments have been made; namely, those with various modifications of the perfusion method, and those with isolated rings of artery (after Meyer ( I ) ) .By perfusion of isolated hearts, neither Sch~ifer (2) nor Langendorff (3) were able to prove a vasomotor influence. Elliott (4) perfused a single vessel on a resting strip of cat's ventricle and observed an increased flow after adrenalin. Wiggers (5) believes he has proved that vasoconstriction results from adrenalin perfusion. Campbell (6) obtained, as a rule, no effect, but in some cases there was slight constriction. Brodie and Cullis (7) have recently concluded that very small doses (not large enough to alter the heart action) produce vasoconstriction only, while with larger doses (augmenting heart action) this effect is soon superseded by vasodilatation. This latter effect, however, they cannot entirely ascribe to metabolites from the ,heart, and they therefore conclude that the coronaries possess constrictors and dilators, both of sympathetic origin (8). Bond's (9) perfusion experiments on the living dog, while inconclusive as to vasomotor action, indicate that, in this animal at least, changes in the rate of coronary flow are parallel to changes in general arterial blood pressure.
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