In laboratory rodents, concentrations of reduced glutathione (GSH) are exceedingly high (up to 7 to 8 millimolar) in the glandular gastric tissue compared to concentrations in other portions of the gastrointestinal tract or to those of most other organs. Gastric GSH varies diurnally, with the highest levels occurring in the late afternoon or early evening. Starvation, treatment with diethyl maleate, or cold-restraint stress all caused marked decreases in stomach GSH, whereas treatment with cobaltous chloride caused an increase in the GSH concentrations. The physiological significance of the high gastric GSH is unknown, but because this endogenous compound may strongly modulate (decrease or increase) the macromolecular binding of certain chemicals capable of inducing stomach tumors, the possible role of glutathione in the pathogenesis of chemically induced gastric cancer should be considered.
Amino acids were determined by ion exchange chromatography on soybean hulls, dehulled soybean meal, isolated soybean protein, and the residue; on whey proteins obtained by isolation of thb acid-precipitated protein; and on the hypocotyl and the acidprecipitated protein of the hypocotyl. Pretreatment of meal and other fractions prior to colorimetric determination of tryptophan is described. Essential amino acid composition of soybean meal fractions varied considerably indicating that biological values of the protein in these fractions also differ. Soybean hulls contained unusually large amounts of glycine and hydroxyproline. Dehulled meal and residue contained no hydroxyproline.EARLY 9 million tons of high-protein
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