Abstract. The paper discusses the influence from measurement uncertainty in case of acceptance sampling by variables. Two kinds of measurement uncertainty are considered in this paper, one is the pure random noise changing from one item to the other. The other type of measurement error considered is a constant error on all items in a lot, but where the error varies from lot to lot. The largest deterioration on the operating characteristics is seen from the low frequency measurement error type.
Sampling of batches studied for validation is reported. A thief particularly suited for granules, rather than cohesive powders, was used in the study. It is shown, as has been demonstrated in the past, that traditional 1x to 3x thief sampling of a blend is biased, and that the bias decreases as the sample size increases. It is shown that taking 50 samples of tablets after blending and testing this subpopulation for normality is a discriminating manner of testing for homogeneity. As a criterion, it is better than sampling at mixer or drum stage would be even if an unbiased sampling device were available.
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