The strongly cytotoxic, antibiotic, and immunosuppressive palau'amine was isolated from the Belau sponge Stylotella aurantium, along with less active 4-bromo and 4,5-dibromo derivatives. Three corresponding isomeric compounds, all less active, were also isolated, and full details of the isolation and all structure proofs are provided.
Citreoviridin A (1a), one of the most dangerous mycotoxins, has ben found in extremely high concentration in the mold Aspergillus terreus. This fungus, one of the commonest organisms occurring in soil and on grain and sugar‐containing foodstuffs, is also utilized in biotechnology. Compound (1a) is accompanied by similar metabilites.
Palau'amine and Its Congeners: A Family of Bioactive Bisguanidines from the Marine Sponge Stylotella aurantium.-The strongly cytotoxic, antibiotic, and immunosuppressive alkaloid palau'amine (Ia) is isolated from a Belau sponge of revised species Stylotella aurantium in addition to the less active bromo compounds (Ib), (Ic), and isopalau'amine derivatives (II). The relative stereochemistry of (Ia) is elucidated by spectroscopic means. Identical CD spectra indicate that (I) have probably the same absolute configuration as monobromophakellin hydrochloride. -(KINNEL, R. B.; GEHRKEN, H.-P.; SWALI, R.; SKOROPOWSKI, G.; SCHER, P. J.; J.
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