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This chapter presents some examples of recent initiatives by social enterprises using aquaponics. Aquaponics offers an innovative form of therapeutic horticulture, which can provide employment and promote well-being for people with disabilities. If implemented as a program to be managed by local communities, aquaponic systems also have the potential to address issues such as food security and food sovereignty, especially in urban areas. Increasing public familiarity with aquaponics has seen a number of social ventures being set up around the world. However, the viability of these depends not only on stakeholder commitment, thorough market analysis, clear governance structures, and a robust business plan but also on external factors, such as the local political context and regulations.