The killing potential of various aminoglycoside antibiotics for Myco bacterium leprae infection of the mouse fo ot-pad was studied, utilizing daily intraperitoneal therapy. Kanamycin (100 mg/kg), streptomycin (150 mg/kg), and amikacin (100 mg/kg) resulted in impressive killing of bacilli (99• 7%, 97% and 96% bactericidal, respectively). Gentamicin (20 mg/kg) and tobramycin (20 mg/kg) were much less active (60% and 37% bactericidal). The bactericidal activity of these very high doses of kanamycin, streptomycin and amikacin compared favourably with those of other agents previously studied in a similar manner at relatively lower dosage levels. Aminoglycoside antibiotics have received only limited experimental and/or clinical attention for their potential role in the therapy of leprosy. 1-9 In 1964 the first study8 on the activity of streptomycin in the treatment of experimental My cobacterium leprae infection of the mouse fo ot-pad was reported. In this study, 2 mg of streptomycin injected subcutaneously 5 times weekly, con tinuously fr om the time of infection, prevented multiplication of M. leprae fo r the 15!-month study duration. In a later study (1968)7 M. leprae-infected mice were treated by the 'kinetic method' with 2 mg of streptomycin 3 times a week fr om day 30 to 86 fo llowing infection. The growth of M. leprae was fo und to be inhibited during the period of drug administration but resumed promptly when therapy was discontinued, suggesting that streptomycin was purely bacteriostatic. More
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