A Pd/Cu‐catalyzed base mediated domino process of ortho‐halo (hetero)aryl carboxaldehydes and propargyl alcohols unexpectedly furnish 2‐(hydroxymethylene)indenones in good to excellent yield as a result of a coupling‐isomerization‐cycloisomerization reaction (CICIR). In addition, the title compounds constitute an interesting class of luminophores with tunable emission solvatochromicity.
A one‐pot four‐component synthesis of thieno[2,3‐d]pyrimidin‐4‐amines via sequential Gewald/cyclocondensation reactions is described. 2‐Aminothiophene‐3‐carbonitriles obtained from the Gewald reaction between cyclic ketones, malononitrile, and sulfur underwent a condensationcyclization reaction with benzonitriles under solvent‐free conditions to afford the title compounds in excellent yields.
A concise synthesis of quinoline-fused eightmembered rings from simple starting materials is described. Reductive cyclo-carbopalladation of suitable Ugi-4CR substrates as a key step leads to the regio-and diastereoselective formation of 1,2-dihydroazocino[4,3-b]quinolin-3-ones under mild reaction conditions with good yields in short reaction time.
A novel domino cycloisomerization of 1,3-dien-5-ynes for the synthesis of 7H-benzo[7]annulenes is reported. The noticeable feature of this domino reaction involves the assembly of the fused bicyclic motifs through a...
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