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PURPOSE Breast cancer (BC) in young women is uncommon and tends to present with more aggressive characteristics. To better understand and characterize this scenario in Brazil through real-world data, we performed a subanalysis of AMAZONA III study (ClinicalTrials.gov identifier: NCT02663973 ). METHODS The AMAZONA III study (GBECAM 0115) is a prospective registry that included 2,950 women newly diagnosed with invasive BC in Brazil from January 2016 until March 2018 at 22 sites. Valid data were obtained from 2,888 patients regarding age at diagnosis and complete baseline information. To compare epidemiologic and clinicopathological features at the time of diagnosis, patients with BC were divided into two groups according to age: ≤ 40 years and > 40 years. Quantitative variables were described as means, and categorical variables were described as frequencies and percentages and compared using the Pearson’s χ2 test. RESULTS Of 2,888 women diagnosed with BC, 486 (17%) were ≤ 40 years old. Young women had higher educational level, most were employed and a significant number were married ( P < .001 for all associations). Younger patients were more symptomatic at BC diagnosis ( P < .001), and they also presented more frequently with stage III, T3/T4, grade 3 tumors, HER-2–positive, luminal B, and triple-negative subtypes. CONCLUSION Brazilian women younger than age 40 years have unfavorable clinicopathological features of BC at diagnosis, with more aggressive subtypes and advanced stage when compared with older women. These differences are not explained by socioeconomic or ethnic imbalances. The causes of a higher prevalence of BC among young women in Brazil deserve additional investigation.

O câncer de mama é a segunda neoplasia mais comum no mundo. Buscou-se descrever variáveis clínico-patológicas em mulheres diagnosticadas com câncer de mama, atendidas no Hospital HINJA, em Volta Redonda-RJ. Os dados foram colhidos em análise guiada por ficha de coleta do Registro Hospitalar. O cruzamento de dados e análise estatística foram realizados com auxílio do programa Excel, e o estadiamento prognóstico, com base no sistema TNM, AJCC, 8ª edição. Foram analisados 140 prontuários e 70 foram incluídos. As pacientes analisadas tiveram a primeira consulta no Hospital HINJA, no período de 11/2012 a 03/2017. Identificou-se prevalência em pacientes com média de 58 anos, brancas e casadas. A maioria das pacientes apresentou estadiamento clínico II, predominando a faixa etária de 50-59 anos. O carcinoma ductal infiltrante foi o mais encontrado, assim como a positividade para o receptor de estrogênio. No estadiamento prognóstico, 23,43% mudaram de IIA para IB. A maioria das pacientes possuía Ki-67>14%. Todas as pacientes realizaram cirurgia, sendo 40% mastectomia.

Background: Currently, there are broadly differing patterns in the management of the axilla after neoadjuvant chemotherapy (NAC) and no consensus with clinically strong evidence on the subject. A survey was performed to assess the current axillary management after NAC among Brazilian breast cancer surgeons. Methods: The Brazilian Society of Mastology members were invited by email to complete an anonymous online survey and a total of 426 responses were collected. How to cite this article: Frasson AL, Resende HM, Lichtenfels M, et al. Axillary management for patients with breast cancer after neoadjuvant chemotherapy: Results of a survey among Brazilian breast surgeons.

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