The efficient synthesis of sixteen 5-arylidene-2,4-thiazolidinediones by aldol condensation reaction of 2,4-thiazolidinedione, mono- and di-substituted arenealdehydes and KOH using ultrasound irradiation is reported. The desired compounds were obtained in a few min (10-30 min) with moderate to good yields (25-81%).

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3,4-(Methylenedioxy)aniline as Precursor to the Synthesis of Thiazolidin-4-ones (IV). -These referred heterocycles (IV) are potent biologically active compounds due to the presence of two important moieties, thiazolidinone and 1,3-benzodioxole. -(MASTELOTO, H. G.; DRAWANZ, B. B.; BERWALDT, G. A.; NEUENFELDT, P. D.; SIQUEIRA, G. M.; CUNICO*, W.; Monatsh. Chem. 146 (2015) 2, 327-334, http://dx.doi.org/10.1007/s00706-014-1338-y ; Lab. Quim. Apl. Bioativos, Univ. Fed. Pelotas, 96010 Pelotas, RS, Brazil; Eng.) -A. Forchert 30-183