In 1954, Arias-Stella described atypical, focal, adenomatous changes in the endometrium arising as a result of the presence of chorionic tissue in the body. I t was possible to demonstrate these changes in both intra-uterine and extra-uterine pregnancy and also in the case of hydatidiform mole and chorionepithelioma. Endometrial changes of this kind in a case of extra-uterine pregnancy are now described."The endometrial glands presented a mixed and atypical pattern. In some areas the glands were of a definite proliferative type, with tall cells showing deep-staining nuclei, marked reduplication, and numerous mitoses. I n other zones, but to a much smaller extent, the glandular pattern was frankly .secretory, with vacuolated cells, marked infolding, and intraluminal budding. Glandular dilation with formation of cysts was also noted. Large or limited portions of the glands in these areas presented atypical cellular changes. These portions were characterized by a cellular enlargement due to nuclear hypertrophy and cytoplasmic vacuolation. The cells appeared deformed and filled with vacuoles of different diameters and in more advanced stages showed breakdown of the protoplasmic membrane. The nuclei were enlarged to from three to four times the size of the normal cells and were round, ovoid, vesicular, or oddly distorted. The chromatin was
The antiovulatory effect of 0.1 milligram ethinyl estradiol during the fifth to the twenty-fifth day of the cycle, followed by 1 milligram megestrol acetate during the twenty-first to the twenty-fifth day, was examined in 19 fertile women.We followed 118 menstrual cycles, one to twelve cycles (average 6.2 cycles) in each patient.During the treatment the cycles were well regulated, with a cycle length of about 28-30 days and bleeding of four to six days' duration.The side effects were like those seen by other authors. Nausea and oedemas were the most frequent troubles, seen in 11.9 and 8.5% of all cycles. In no case did the side effects cause discontinuation of the treatment.The ~itiovulatory effect was examined in the following ways: 1. The p r e~~e d i o l excretion in the morning urine was measured thinlayer-chromatograp~c~ly according to Bang (1964). Based upon the excretion during the 9th to the 4th day before menstruation, the probability of ovulation in 113 cycles was found to be less than 0.025.In one cycle the probability of ovulation was 0.05, whereas the excretion in one cycle indicated ovulation. Three cycles were not sufficiently investigated.2. The basal rectal temperature curves were found to be monophasic in 99 cycles. In 14 cycles a slight rise in temperature was seen following the gestagen medication, and in one cycle a typical ovulatory rise in temperature was seen. The basal temperature was not followed in four cycles.
52
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.