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The present study analyzes the relationship between maladaptive beliefs, personality traits, and Borderline Personality Disorder symptoms by focusing in the mediating role of beliefs in the prediction between personality and psychiatric disorders. The sample consisted of 823 adults aged between 18 and 39 years (M = 24.09, SD = 4.71), who answered a questionnaire of symptoms and beliefs for Borderline Personality Disorder and Big Five Personality Inventory. The predictive model that fit better to the data indicates Neuroticism and Conscientiousness as predictors of Borderline Personality Disorder symptoms, mediated by maladaptive belief patterns. In this sense, it is possible to conclude that both personality traits and maladaptive beliefs are important for the understanding of Borderline Personality Disorder. The theoretical implications of this result and the limitations of the study are discussed.