Resumo: O estudo sobre as interações das redes moleculares ligadas ao câncer torna necessária a centralização de dados biológicos, pois as informações estão espalhadas por diversos sistemas públicos de armazenamento. Visando a tal unificação, propõe-se a ontologia Ontocancro 4 , para modelar os dados relevantes ao estudo do pesquisador através de uma interface web, que proporciona uma pesquisa direta e consistente, garantindo unicidade das informações.
The evolution of studies and learning about the functioning of the human genome made gene expression techniques increasingly explored and applied in recent years' research. There is a need for a deeper understanding of these materials' toxicology in bioinformatics and nanotechnology. Therefore, the present work aims to present the gene expression levels of three studies using three different human cell lines (co-culture of Caco-2/HT29-MTX, SAE, and THP-1 cells), submitted to NPs of carbon dioxide of titanium, via free bioinformatics tools, such as the Limma package (Bioconductor) and Reactome. The data were prepared and standardized by executing the Limma package (Bioconductor), and the results of the most and least expressed genes were used in Reactome. Results show the activation of some genes in common to the experiments, highlighting the co-culture samples of Caco-2/HT29-MTX and THP-1 cells treated with titanium dioxide Nps.
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