We have been continuing a study1 of the effects of certain substances on gastric secretion in the pylorus-ligated rat. Davenport et al.f1 reported the inhibitory effects of AT-ethylmaleimide and iodoacetamide on gastric secretion in vitro. More recently, Hollander3 confirmed and amplified this observation in vivo: topical application of solutions of these substances to canine gastric mucosa resulted in secretory inhibition. In this study we have investigated the inhibitory effect on gastric secretion, in vivo, of injected Y-ethylmaleimide, N-2fluorenylmaleimide (new substance, m.p. 187 •5-188°, cor.), ß-mercaptoethylamine hydrochloride"]• and the closely related 2-aminoethyhsothiuronium bromide hydrobromide (AET). Since we found a decrease in secretory activity with each of these separately, we devised experiments seeking possible ' neutralizing ' effects of the sulphydryl type compounds on subsequently injected maleimides. There appears to be such an effect.
Materials and MethodsSprague-Dawley rats (250-300 g) fasted for 72 h and deprived of water just preceding the operation, were lightly anaesthetized with ether and the pylorus of each was ligated (Shay4 preparation).
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